Pyxis CIISafe® System

Controlled substance management

The Pyxis® CIISafe® system from CareFusion stores, tracks and monitors the replenishment of controlled substance inventory within your hospital. The Joint Commission, DEA and other regulatory agencies are placing greater importance on the need to account for all controlled substances at all times – and for good reason. Reporting errors and drug diversion not only carry the risk of infractions that may affect accreditation status, result in costly fines and revoked licenses, they can also jeopardize patient safety.

The Pyxis CIISafe system brings enhanced value to existing Pyxis MedStation™ system users, providing seamless hospital-wide management of controlled substances. The technology streamlines documentation from the pharmacy to the nursing floor, virtually eliminating time-consuming and error-prone manual recordkeeping. It also makes it easier to quickly spot discrepancies or signs of diversion.


  • The Pyxis CIISafe system helped Alliance Community Hospital create an electronic audit trail that helped them close the loop on controlled substance management and maintain compliance with DEA requirements.1
  • The Hospital of Saint Raphael launched a proactive diversion monitoring program using the information provided by the Pyxis MedStation system and Pyxis CIISafe system. Now they are focused on preventing rather than reacting to diversion incidents.2
  • Accurate and easily retrievable real-time data helps effectively manage controlled substance inventory.

Please refer to federal, state and local laws and regulations applicable to your hospital or pharmacy location in order to comply with specific requirements for the storage of the controlled substances.

  1. Alliance Community Hospital. CareFusion case study. 2008. DI2424
  2. Making Measurable Improvements in Safety, Efficiency and Cost. Hospital of Saint Raphael. CareFusion case study. 2008, DI2098